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Fifty-nine labs around the world handle the deadliest pathogens – Wuhan is one of them
Only a quarter score high on safety
A massive expenditure by the Wuhan Institute of Virology shortly before the pandemic began.
This is a lot of money to refurbish an existing air conditioning and purification plant on a building built for purpose only 15 years earlies at a cost of $45 million. For perspective, Microsoft is building a new data-centre campus on 53 acres near Chicago for somewhere between $450 million and $500 million. The Wuhan Institute of Virology wanted to spend more than that just to renovate its HVAC system.
Wuhan Institute of Virology had equipment problems in the year before COVID-19 appeared in the surrounding city: “The references to maintenance at the BSL-3 and animal center at the WNBL, the procurement of an environmental air disinfection system, and renovations to the hazardous waste treatment system and central air conditioning system all raise questions about how well these systems were functioning in the months prior to the outbreak of COVID-19.
Why would China’s bill to replace an air-conditioning system be six times the cost of building a new lab.
The preponderance of evidence suggests SARS-CoV-2 was accidentally released from a Wuhan Institute of Virology laboratory sometime prior to September 12, 2019.
The first disputable contention is when the report notes that, “athletes at the Military World Games held in Wuhan in October 2019 who became sick with symptoms similar to COVID-19 both while in Wuhan and also shortly after returning to their home countries.”
The second disputable contention is that “satellite imagery of Wuhan in September and October 2019 that showed a significant uptick in the number of people at local hospitals surrounding the WIV’s headquarters.
The Wuhan BSL-4 lab was constructed as a result of an agreement between China and France that was signed after the 2003 SARS pandemic. In 2016, the China requested dozens of the containment suits required to work in the lab. The French Dual-Use Commission, tasked with considering exports of sensitive equipment, rejected their request.
Known as biosafety level 4 (BSL4) labs, these are designed and built so that researchers can safely work with the most dangerous pathogens on the planet – ones that can cause serious disease and for which no treatment or vaccines exist. Researchers are required to wear full-body pressurised suits with independent oxygen.
With 3,000m² of lab space, the Wuhan Institute of Virology is the largest BSL4 lab in the world.
“There are no binding international standards for safe, secure, and responsible work on pathogens,”
Human H1N1 virus — the same flu that caused the 1918 pandemic — leaked in 1977 in the Soviet Union and China and spread worldwide. In 2001, a mentally disturbed employee at a US biolab mailed out anthrax spores across the country, killing five people. Two Chinese researchers exposed to SARS in 2004 spread the disease to others, killing one. In 2014, a handful of smallpox vials were uncovered during a Food and Drug Administration office move.
This field has long been contentious. Debate reached a fever pitch when two research teams in 2011 showed they could make bird flu transmissible between mammals. “That it would create a strain of virus that if it infected a laboratory worker could not just kill that laboratory worker… but also cause a pandemic.”
SAGE (Scientific Advisory Group for Emergencies) meeting on Wuhan Coronavirus (COVID 19) 22 January 2020
Current understanding of Wuhan Coronavirus (COVID 19).
There is evidence of person-to-person transmission. It is unknown whether transmission is sustainable.
The incubation period is unclear – but appears to be within 5 to 10 days: 14 days after contact is a sensible outer limit to use.
It is highly probable that the reproductive number is currently above 1.
It is currently estimated that the mortality rate for WN-CoV is lower than for SARS, but it is too early to reliably quantify that rate.
There is no evidence yet on whether individuals are infectious prior to showing symptoms.
COBRA (Civil Contingencies Committee) 24 January 2020
The meeting was told a silent and stealthy killer was creeping across the world. Passing from person to person and borne on ships and planes, the coronavirus was already leaving a trail of bodies.
The virus had spread from China to six countries and was almost certainly in many others. Sensing the coming danger, the British government briefly went into wartime mode that day, holding a meeting of Cobra, its national crisis committee.
But it took just an hour, that lunchtime, to brush aside the coronavirus threat. Matt Hancock, the health secretary, bounced out of Whitehall after chairing the meeting and breezily told reporters the risk to the UK public was “low”.
Third SAGE meeting on Wuhan Coronavirus (WN-CoV), 3 February 2020
On the expected impact of travel restrictions, SAGE estimates – with limited data – that if the UK reduces imported infections by 50%, this would maybe delay the onset of any
epidemic in the UK by about 5 days; 75% would maybe buy 10 additional days; 90% maybe buys 15 additional days; 95%+ maybe buys a month.
Only a month of additional preparation time for the NHS would be meaningful. It would also be meaningful if the outbreak were pushed out of usual winter respiratory season.
Boris Johnson skipped multiple emergency meetings on the coronavirus in January and February 2020 as it spread rapidly across the world.
By the time Johnson appeared at the first Cobra meeting to discuss the virus on 3 March 2020, more than 40 people had already tested positive for COVID-19.
The report also claimed that the government failed to act on warnings from scientists about the virus.
Boris Johnson skipped five Cobra meetings on the virus, calls to order protective gear were ignored and scientists’ warnings fell on deaf ears. Failings in February 2020 may have cost thousands of lives.
SAGE meeting dealing with covid 19 (May 2020)
Attendees; Five Sirs, Thirty-five Professors, Fifteen Doctors and one Mister.
The meeting noted that it is currently hard to interpret the biological consequences of sequence variations in the virus — but acknowledged the ramifications of mutation and virus recombination in areas such as diagnostics and vaccines.
The meeting agreed that the biology of the virus should be the focus of an open research call.
COBRA meetings & comments where Covid 19 was discussed
In 2020, COBRA met 20 times to discuss the Covid-19 pandemic, first meeting in January 2020, before any cases had been recorded in the UK. It met 15 times from January to May but did not meet at all between 10 May and 22 September.
The prime minister, Boris Johnson, did not attend the first five Covid-related COBRA meetings in January and February 2020. While Boris Johnson was ill with Covid in late March/early April 2020, Foreign Secretary Dominic Raab chaired COBRA in his place. Michael Gove, minister for the Cabinet Office and chancellor of the duchy of Lancaster, has also on occasion chaired COBRA meetings, mostly during the second wave of Covid-19 which started in September.
One SAGE member described COBRA as a “void of decision making” at the centre of government. In the early stages of the crisis, it was not always clear to officials who was taking which decisions. And COBRA was not supported to commission specific pieces of scientific analysis from SAGE, meaning the scientific advisers were unable to provide useful answers.
SAGE meetings & comments where Covid 19 was discussed.
Decision making in a crisis Published: 01 September 2020
The government’s initial response to the Covid-19 crisis was hampered by the absence of a long-term strategy, lack of clarity about who was responsible for what and its poor use of evidence.
Covid crisis mistakes will be repeated unless government improves use of science advice Published: 18 December 2020
Event 201 (18 October 2019) New York USA.
The Johns Hopkins Center for Health Security in partnership with the World Economic Forum and the Bill and Melinda Gates Foundation hosted Event 201, a high-level pandemic exercise, in New York, NY. The exercise illustrated areas where public/private partnerships will be necessary during the response to a severe pandemic to diminish large-scale economic and societal consequences.
In recent years, the world has seen a growing number of epidemic events, amounting to approximately 200 events annually. These events are increasing, and they are disruptive to health, economies, and society. Managing these events already strains global capacity, even absent a pandemic threat. Experts agree that it is only a matter of time before one of these epidemics becomes global—a pandemic with potentially catastrophic consequences. A severe pandemic, which becomes “Event 201,” would require reliable cooperation among several industries, national governments, and key international institutions.
As an independent monitoring and advocacy body, the Global Preparedness Monitoring Board (hereafter referred to as the Board or GPMB) urges political action to prepare for and mitigate the effects of global health emergencies. Co convened in May 2018 by the World Bank Group and the World Health Organization, the Board builds on the work of the Global Health Crises Task Force and Panel, created by the United Nations Secretary-General in the wake of the 2014-2016 Ebola epidemic. The Board works independently of all parties, including its co-conveners, to provide the frankest assessments and recommendations possible.
And we must not forget
The New and Emerging Respiratory Virus Threats Advisory Group (NERVTAG) is an advisory body that advises the United Kingdom Government’s Chief Medical Advisor / Chief Medical Officer for England, who in turn advises the UK Department of Health and Social Care and relevant ministers regarding threats from viral respiratory tract infections. The body replaced the UK Scientific Pandemic Influenza Advisory Committee (SPI).
The Advisory Committee on Dangerous Pathogens (ACDP) is a UK-wide advisory committee. It was established in 1981, and the terms of reference were revised in 1991 to allow for a wider remit.